2-CYANOPHENOL (2-HYDROXYBENZONITRILE)
2-Cyanophenol
CAS: 611-20-1
Molecular Formula: C7H5NO
2-CYANOPHENOL (2-HYDROXYBENZONITRILE) - Names and Identifiers
| Name | 2-Cyanophenol |
| Synonyms | 2-Cyanophenol O-CYANOPHENOL o-cyanophenol 2-cyano phenol Salicylonitrile SALICYLONITRILE Salicylic nitrile 2-Hydroxy-benzonitril O-HYDROXYBENZONITRILE 2-Hydroxybenzonitrile 2-Hydroxy benzonitrile SALICYLIC ACID NITRILE O-hydroxybanzo nitrile 2-CYANOPHENOL (2-HYDROXYBENZONITRILE) |
| CAS | 611-20-1 |
| EINECS | 210-259-3 |
| InChI | InChI=1/C7H5NO/c8-5-6-3-1-2-4-7(6)9/h1-4,9H |
2-CYANOPHENOL (2-HYDROXYBENZONITRILE) - Physico-chemical Properties
| Molecular Formula | C7H5NO |
| Molar Mass | 119.12 |
| Density | 1.1052 |
| Melting Point | 92-95 °C (lit.) |
| Boling Point | 149 °C/14 mmHg (lit.) |
| Flash Point | 149°C/14mm |
| Water Solubility | soluble |
| Solubility | Chloroform (Sparingly), Methanol (Slightly) |
| Vapor Presure | 0.17Pa at 25℃ |
| Appearance | White to bright yellow crystalline powder |
| Color | Off-white to brown |
| BRN | 1210029 |
| pKa | 6.86(at 25℃) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| Refractive Index | 1.5372 |
| MDL | MFCD00002145 |
| Physical and Chemical Properties | Crystallization. Melting point 92-95 °c (102-102.5 °c), boiling point 149 °c/1.9kPa(14mmHg). |
| Use | Used as a pharmaceutical Intermediate |
2-CYANOPHENOL (2-HYDROXYBENZONITRILE) - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3276 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29269095 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
2-CYANOPHENOL (2-HYDROXYBENZONITRILE) - Reference Information
| LogP | 1.66 at 30℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | O-hydroxybenzonitrile, commonly known as salicylonitrile, is an off-white powdery solid with a pungent odor, A small amount can be affected by the breath, the smell is bitter; If a small amount of salicylic nitrile is opened in the state of no ventilation, the smell can be quickly spread throughout the room; Therefore, the operation must be done Protection Measure, reduce the irritation of the respiratory tract; Used as an intermediate of organic synthesis of bunilor, fungicide azoxystrobin intermediate. With a certain water solubility, Pka = 7.17, unstable to strong alkali and oxidant. |
| Use | O-hydroxybenzonitrile can be used as a pharmaceutical intermediate, which can be used as a synthetic drug for the treatment of hypertension and angina pectoris, the bactericide azoxystrobin can be synthesized, and in addition, a variety of perfumes and liquid crystal materials can be synthesized. An intermediate of Bunolol. used as pharmaceutical intermediates can be used in the synthesis of Bunolol. |
| reagent uses | O-hydroxybenzonitrile is used in the synthesis of a CDK / GSK-3 inhibitor and as a therapeutic agent for Alzheimer's disease. |
| production method | The product was prepared by condensing salicylaldehyde with hydroxylamine hydrochloride to produce salicylaldoxime, and then reacting with acetic anhydride and hydrolyzing. |
Last Update：2024-04-09 15:16:51
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